| Expression pattern: |
DN |
| Associated gene: |
YAP1 |
| Associated microRNA: |
- |
| Biological function: |
Potentially influences the occurrence and development of colorectal cancer and serves as a noninvasive prognostic/diagnostic biomarker; lower expression is associated with poorer overall survival. |
| Molecular mechanism: |
Bioinformatics analyses (PPI and enrichment of YAP1-similar genes) suggest involvement in ubiquitination-related processes; no direct ceRNA/protein-binding mechanism experimentally validated. |
| Biological pathway or process: |
ubiquitination (other); other pathway/process (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Survival Analysis; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Decreased in CRC plasma/tissues; higher expression predicts longer overall survival and shows diagnostic value (AUC 0.823). |
| Description: |
hsa_circ_0002320 (host gene YAP1) is down-regulated in CRC plasma and tumor tissues. Higher hsa_circ_0002320 is associated with longer overall survival and shows good diagnostic performance (ROC AUC 0.823), suggesting it as a noninvasive prognostic/diagnostic biomarker; bioinformatics links it to ubiquitination-related processes. |
| Confidence score: |
0.5121 |