| Expression pattern: |
DN |
| Associated gene: |
TGFBR2 |
| Associated microRNA: |
miR-942-5p |
| Biological function: |
represses proliferation, migration and invasion; promotes apoptosis; increases gefitinib sensitivity; inhibits tumor growth under gefitinib |
| Molecular mechanism: |
circ_MACF1 acts as a sponge of miR-942-5p to de-repress TGFBR2 expression (ceRNA regulation). |
| Biological pathway or process: |
proliferation (inhibits); apoptosis (promotes); migration (inhibits); invasion (inhibits); ceRNA regulation (other); drug resistance (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Nuclear-Cytoplasmic Fractionation; RNase R Treatment; Transfection; MTT; EdU Staining; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Luciferase Reporter Assay; RNA Pull-Down; In Vivo Animal Model; Western Blot; IHC (Immunohistochemistry); Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
down-regulated circ_MACF1 in gefitinib-resistant NSCLC plasma vs pre-gefitinib treated plasma, suggesting association with gefitinib resistance |
| Description: |
circ_MACF1 is down-regulated in gefitinib-resistant NSCLC (cells and patient plasma). Restoring circ_MACF1 suppresses malignant behaviors and enhances gefitinib sensitivity by sponging miR-942-5p and thereby increasing TGFBR2 expression, leading to reduced tumor growth under gefitinib in vivo. |
| Confidence score: |
0.8175 |