| Expression pattern: |
UP |
| Associated gene: |
CAMSAP2, Ago2 |
| Associated microRNA: |
miR-2355-5p |
| Biological function: |
Promotes NSCLC cell proliferation, migration, invasion, cell cycle progression and EMT; its silencing suppresses malignant behaviors. |
| Molecular mechanism: |
Acts as a ceRNA sponge for miR-2355-5p to modulate CAMSAP2; miR-2355-5p binds to the CircSOD2 promoter and activates circSOD2 expression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); cell cycle (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Transfection; CCK8; Transwell Assay; Western Blot; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
CircSOD2 can be a potential biomarker for NSCLC diagnosis. |
| Description: |
CircSOD2 is up-regulated in NSCLC tissues and cell lines and promotes malignant phenotypes including proliferation, migration/invasion and EMT. Mechanistically, CircSOD2 functions as a ceRNA sponging miR-2355-5p to relieve repression of CAMSAP2, forming a CircSOD2/miR-2355-5p/CAMSAP2 axis. |
| Confidence score: |
0.7754 |