circRNA basic information
circBase ID: -
Name: rno_circ_HIPK3
Synonym: -
Host Gene: HIPK3
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001150
MONDO name: hydrocephalus
Disease details: communicating hydrocephalus after intraventricular hemorrhage
Disease DO ID:
 10908
Disease MeSH ID:
 D006849
Disease NCIt ID:
 C3111
Disease ICD11 ID:
 574533444
Disease OMIM ID:
 -
Species: Rat
Species details: Rattus norvegicus
Tissue specimen:

meningeal tissues; meninges; periventricular brain tissue
Cell lines:

CTX TNA2; CTX cells; 293 T
In vivo animal model:

other disease animal model
circRNA-disease information
Expression pattern:
UP
Associated gene: ACT1(TRAF3IP2), TGF-beta1, Smad3, Col1, alpha-SMA
Associated microRNA: miR-30a-3p
Biological function: circHIPK3 promotes meningeal fibrosis, ventricular dilation, neurological dysfunction, and post-IVH communicating hydrocephalus progression; knockdown attenuates meningeal fibrosis, reduces ventricular dilation, and improves neurological function.
Molecular mechanism: circHIPK3 acts as a miR-30a-3p sponge, derepresses ACT1(TRAF3IP2), activates the TGF-beta1/Smad3 signaling pathway, and drives fibrotic progression after IVH.
Biological pathway or process:

TGF-beta/SMAD (promotes); fibrosis (promotes); ceRNA regulation (other); other pathway/process (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; FISH / smFISH; Luciferase Reporter Assay; RNA Pull-Down; Bioinformatics Analysis; Transfection; IF (Immunofluorescence); Western Blot; In Vivo Animal Model; H&E Staining
Clinical significance:

circHIPK3 could be a key therapeutic target against post-IVH communicating hydrocephalus.
Description:

In rat IVH and thrombin-stimulated astrocyte models, circHIPK3 is up-regulated and promotes post-IVH communicating hydrocephalus by driving meningeal/periventricular fibrosis. Mechanistically, circHIPK3 sponges miR-30a-3p, increases ACT1(TRAF3IP2), activates TGF-beta1/Smad3 signaling, and promotes fibrotic proteins such as Col1 and alpha-SMA. Knockdown of circHIPK3 alleviates fibrosis, ventricular enlargement, and neurological dysfunction, supporting its potential as a therapeutic target.
Confidence score:

0.657
Other information
Title:

CircHIPK3 regulates TGF-beta1/smad3 signaling in communicating hydrocephalus after intraventricular hemorrhage by sponging miR-30a-3p via ACT1.

Journal: Brain research bulletin
Published: 2026
PubMed ID: 41616946
Study type:

biological research
Data availability: Supplementary data associated with this article can be found in the online version at doi:10.1016/j.brainresbull.2026.111751.
Code availability: -