circRNA basic information
circBase ID: hsa_circ_0060055
Name: hsa_circ_EIF6
Synonym: -
Host Gene: EIF6
Genomic location(hg19): chr20:33866724-33872064:-
Genomic location(hg38): chr20:35278921-35284261:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0009831
MONDO name: malignant pancreatic neoplasm
Disease details: pancreatic cancer
Disease DO ID:
 1793
Disease MeSH ID:
 -
Disease NCIt ID:
 C9005
Disease ICD11 ID:
 542147910
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

normal pancreatic tissue; tumor tissues; lung tissue
Cell lines:

BxPC3; PaCa-2; PANC-1; SW1990; HPDE; HUVECs
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: Bcl-2, Bax, Ki67
Associated microRNA: miR-1298-5p
Biological function: Promotes pancreatic cancer cell proliferation, viability, colony formation, migration, invasion, angiogenesis, vascular leakage and tumor growth, while inhibiting apoptosis.
Molecular mechanism: circ_0060055 acts as a molecular sponge for miR-1298-5p and regulates apoptosis-related proteins Bcl-2 and Bax.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); angiogenesis (promotes); ceRNA regulation (promotes); other pathway/process (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Transfection; CCK8; EdU Staining; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Wound Healing Assay; Tube Formation Assay; IHC (Immunohistochemistry); Western Blot; Luciferase Reporter Assay; In Vivo Animal Model; H&E Staining; Bioinformatics Analysis
Clinical significance:

circ_0060055 could serve as a potential therapeutic target, predictive biomarker and target for therapeutic intervention in PDAC.
Description:

hsa_circ_0060055/circ_0060055 is up-regulated in pancreatic cancer cell models and functions as an oncogenic circRNA. It promotes proliferation, migration, invasion, angiogenesis, vascular leakage and xenograft tumor growth while reducing apoptosis. Mechanistically, it sponges miR-1298-5p and is associated with changes in apoptosis-related proteins Bcl-2 and Bax, suggesting potential therapeutic relevance in PDAC.
Confidence score:

0.6545
Other information
Title:

The upregulated RNA circ_0060055 regulates the proliferation, invasion and apoptosis of pancreatic cancer cells through spongy miR-1298-5p.

Journal: Medical oncology (Northwood, London, England)
Published: 2026
PubMed ID: 41615581
Study type:

biological research
Data availability: -
Code availability: -