circRNA basic information
circBase ID: hsa_circ_0070190
Name: hsa_circ_BMP2K
Synonym: -
Host Gene: BMP2K
Genomic location(hg19): chr4:79747190-79772210:+
Genomic location(hg38): chr4:78826036-78851056:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

PBMCs
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-4659b-3p, hsa-miR-3614-3p, hsa-miR-4659a-3p
Biological function: Potential diagnostic biomarker for HCC.
Molecular mechanism: Predicted circRNA-miRNA-mRNA regulatory network (bioinformatics).
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Potential diagnostic biomarker for HCC (ROC analysis performed).
Description:

hsa_circ_0070190 is up-regulated in PBMCs from HCC patients and validated by RT-qPCR. It was evaluated by ROC analysis as a potential diagnostic biomarker and is part of predicted ceRNA networks, with predicted binding to multiple miRNAs including shared sites (hsa-miR-4659b-3p/hsa-miR-3614-3p/hsa-miR-4659a-3p).
Confidence score:

0.5047
Other information
Title:

CircRNA expression profiling of PBMCs from patients with hepatocellular carcinoma by RNA-sequencing.

Journal: Experimental and therapeutic medicine
Published: 2021
PubMed ID: 34737807
Study type:

combined biological and clinical study
Data availability: PRJNA754685
Code availability: -