circRNA basic information
circBase ID: hsa_circ_0000615
Name: hsa_circ_ZNF609
Synonym: -
Host Gene: ZNF609
Genomic location(hg19): chr15:64791491-64792365:+
Genomic location(hg38): chr15:64499292-64500166:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005061
MONDO name: lung adenocarcinoma
Disease details: lung adenocarcinoma
Disease DO ID:
 3910
Disease MeSH ID:
 C538231
Disease NCIt ID:
 C3512
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

LAUD tumor tissues; adjacent normal tissues
Cell lines:

HCC827; NCI-H23; SPC-A1; H1975; H1299; A549; HBE
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: ETV1
Associated microRNA: miR-1224-3p
Biological function: promotes LAUD cell proliferation and cell-cycle progression
Molecular mechanism: ceRNA mechanism: circ-ZNF609 sponges miR-1224-3p to increase ETV1 expression
Biological pathway or process:

proliferation (promotes); cell cycle (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Transfection; CCK8; Colony Formation Assay; Cell Cycle Assay; Western Blot; Bioinformatics Analysis
Clinical significance:

-
Description:

circ-ZNF609 is up-regulated in lung adenocarcinoma tissues and cell lines and promotes tumor cell proliferation and G0/G1-to-S progression. It functions as a ceRNA by sponging miR-1224-3p, thereby increasing ETV1 expression and driving malignant growth.
Confidence score:

0.7277
Other information
Title:

Circular RNA Circ-ZNF609 Promotes Lung Adenocarcinoma Proliferation by Modulating miR-1224-3p/ETV1 Signaling.

Journal: Cancer management and research
Published: 2020
PubMed ID: 32308483
Study type:

combined biological and clinical study
Data availability: -
Code availability: -