| Expression pattern: |
UP |
| Associated gene: |
USP10, p53, HIF1alpha |
| Associated microRNA: |
- |
| Biological function: |
Promotes breast cancer cell proliferation/viability and tumor growth under hypoxia; inhibits apoptosis; promotes cell cycle progression; promotes tumor progression by destabilizing p53. |
| Molecular mechanism: |
Hypoxia/HIF1alpha transcriptionally upregulates circWSB1; circWSB1 directly binds USP10 and competitively disrupts USP10-p53 interaction, increasing p53 ubiquitination and degradation, thereby attenuating p53 signaling (p21, Bax). |
| Biological pathway or process: |
p53 signaling (inhibits); proliferation (promotes); cell cycle (promotes); apoptosis (inhibits); ubiquitination (promotes) |
| Detected method: |
Q
H
M
|
| Validation methods: |
Microarray; RT-qPCR; ISH (In Situ Hybridization); Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; RIP (RNA Immunoprecipitation); RNA Pull-Down; Co-IP; Western Blot; ChIP / ChIP-seq; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay; In Vivo Animal Model; IHC (Immunohistochemistry); Survival Analysis; ROC Analysis; Bioinformatics Analysis; H&E Staining |
| Clinical significance: |
circWSB1 is upregulated in breast cancer tissues, can distinguish BC from non-tumor tissues (ROC), and high circWSB1 is associated with worse overall survival and higher recurrence; it may be an independent prognostic factor. |
| Description: |
In breast cancer, circWSB1 (hsa_circ_0007716) is induced by hypoxia via HIF1alpha and is up-regulated in tumor tissues. circWSB1 promotes tumor cell proliferation and xenograft growth by binding USP10 and disrupting USP10-mediated p53 deubiquitination, resulting in p53 destabilization and suppression of p53 signaling. |
| Confidence score: |
0.8995 |