| Expression pattern: |
DN |
| Associated gene: |
GAS7c, Sam68, PABP1, TNFAIP2 mRNA, TNFAIP2, Rac1, ZNF460 |
| Associated microRNA: |
miR-671-5p |
| Biological function: |
circAAGAB acts as a tumor-suppressive regulator in ESCC, suppressing ESCC cell proliferation, clonogenicity, migration, invasion, tumor growth, and metastasis. |
| Molecular mechanism: |
S. mitis-secreted MLY induces ZNF460 degradation and represses circAAGAB transcription; circAAGAB suppresses ESCC through miR-671-5p/GAS7c/Sam68-mediated inhibition of PI3K/AKT/GSK-3beta signaling and through binding PABP1 to destabilize TNFAIP2 mRNA and inhibit Rac1/ERK/STAT3 signaling. |
| Biological pathway or process: |
PI3K/AKT (inhibits); ERK (inhibits); proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); EMT (inhibits); ceRNA regulation (promotes); mRNA stability (inhibits); other pathway/process (inhibits) |
| Detected method: |
Q
S
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; Actinomycin D / DRB Stability Assay; RT-qPCR; RNA-seq; Clinical Sample Validation; RIP (RNA Immunoprecipitation); RNA Pull-Down; Co-IP; ChIP / ChIP-seq; Luciferase Reporter Assay; Transfection; Colony Formation Assay; Transwell Assay; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); Western Blot; Cohort Study; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
Reduced circAAGAB expression correlated with advanced TNM staging and predicted shorter disease-free survival; circAAGAB was reduced in ESCC tissues and patient plasma, indicating potential prognostic biomarker value. |
| Description: |
circAAGAB is a human AAGAB-derived circRNA that is downregulated in ESCC tissues and patient blood/plasma, and low expression is associated with advanced TNM stage and shorter disease-free survival. It functions as a tumor suppressor by inhibiting ESCC proliferation, clonogenicity, migration, invasion, and tumor progression. Mechanistically, S. mitis-secreted MLY promotes ZNF460 proteasomal degradation to repress circAAGAB, while circAAGAB suppresses oncogenic signaling through the miR-671-5p/GAS7c/Sam68 and PABP1/TNFAIP2/Rac1 axes. |
| Confidence score: |
0.8966 |