| Expression pattern: |
DN |
| Associated gene: |
PTEN, AGO2 |
| Associated microRNA: |
miR-25-3p |
| Biological function: |
inhibits proliferation and invasion; suppresses tumor growth in vivo |
| Molecular mechanism: |
Exosomal circBTG2 acts as a ceRNA/miRNA sponge for miR-25-3p, relieving repression of PTEN. |
| Biological pathway or process: |
proliferation (inhibits); invasion (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RNase R Treatment; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; EdU Staining; Transwell Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
circBTG2 is probably a diagnostic biomarker and potential target for glioma therapy. |
| Description: |
This study identifies exosomal circBTG2 (derived from BTG2) as a suppressor of glioma progression. circBTG2 inhibits glioma cell proliferation and invasion and suppresses xenograft growth by sponging miR-25-3p to increase PTEN expression, suggesting potential diagnostic/therapeutic value. |
| Confidence score: |
0.7795 |