| Expression pattern: |
UP |
| Associated gene: |
BDNF, TGFB1 |
| Associated microRNA: |
miR-361-5p |
| Biological function: |
Key predicted ceRNA with strong potential for miRNA sponging, especially involving miR-361-5p, potentially enhancing downstream targets BDNF and TGFB1. |
| Molecular mechanism: |
Potential ceRNA mechanism through miR-361-5p sponging and downstream BDNF/TGFB1 regulation. |
| Biological pathway or process: |
ceRNA regulation (promotes); MAPK (promotes); TGF-beta/SMAD (promotes); other pathway/process (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RT-qPCR; RNA-seq; Bioinformatics Analysis |
| Clinical significance: |
Linked through predicted downstream hub genes that may serve as potential prognostic biomarkers for HBV-HCC. |
| Description: |
circPROX1 was included in the validated upregulated circRNA set and emerged as one of the key predicted ceRNA-network circRNAs. It was predicted to interact with miR-361-5p and to potentially enhance downstream targets such as BDNF and TGFB1 in HBV-HCC-related signaling. |
| Confidence score: |
0.4761 |