circRNA basic information
circBase ID: -
Name: hsa_circ_UBE2D2
Synonym: circ-UBE2D2
Host Gene: UBE2D2
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

BC tissues; adjacent normal tissues / paracancerous tissues
Cell lines:

MCF-7; T47D; BT-474; BT-20; MDA-MB-231; MCF-10A
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: HOXB7, MTA2, ZEB1, KLF8, AFP, p21, PIK3CB, ANGPT1, GAGE1, CD105, ATF6alpha, EGFR
Associated microRNA: miR-1236, miR-1287
Biological function: Promotes breast cancer cell proliferation, migration and invasion; inhibits apoptosis; promotes tumor growth in vivo.
Molecular mechanism: Acts as a ceRNA/miRNA sponge for miR-1236 and miR-1287, thereby regulating their respective target genes (e.g., HOXB7, MTA2, ZEB1, KLF8, AFP, p21; and PIK3CB, ANGPT1, GAGE1, CD105, ATF6alpha, EGFR).
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; Survival Analysis; Transfection; CCK8; Transwell Assay; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry)
Clinical significance:

High circ-UBE2D2 expression is associated with aggressive clinicopathological features and shorter overall and disease-free survival in breast cancer patients.
Description:

circ-UBE2D2 is up-regulated in breast cancer and promotes malignant phenotypes (proliferation, migration, invasion, tumor growth) while inhibiting apoptosis. It functions mainly as a ceRNA by sponging miR-1236 and miR-1287 to de-repress their downstream target genes, and high expression predicts poorer OS/DFS.
Confidence score:

0.7451
Other information
Title:

Upregulated Circular RNA circ-UBE2D2 Predicts Poor Prognosis and Promotes Breast Cancer Progression by Sponging miR-1236 and miR-1287.

Journal: Translational oncology
Published: 2019
PubMed ID: 31336316
Study type:

combined biological and clinical study
Data availability: GSE101124
Code availability: -