| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
inhibits proliferation; inhibits cell cycle progression; promotes apoptosis |
| Molecular mechanism: |
Predicted ceRNA network (circZNF561-mediated) based on circBank and miRDB; pathway enrichment suggests involvement of PI3K-Akt and MAPK signaling and protein ubiquitination-related processes. |
| Biological pathway or process: |
proliferation (inhibits); cell cycle (inhibits); apoptosis (promotes); PI3K/AKT (other); MAPK (other); ubiquitination (other); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Bioinformatics Analysis |
| Clinical significance: |
circZNF561 is decreased in prostate cancer tissues and plasma samples and is suggested as a potential diagnostic biomarker. |
| Description: |
circZNF561 is down-regulated in prostate cancer tissues, cell lines, and patient plasma. Knockdown experiments indicate it restrains proliferation and cell-cycle progression and supports apoptosis, consistent with a tumor-suppressive role. A predicted ceRNA network suggests potential links to PI3K-Akt/MAPK signaling and ubiquitination-related processes. |
| Confidence score: |
0.568 |