circRNA basic information
circBase ID: hsa_circ_0038632
Name: hsa_circ_PLK1
Synonym: -
Host Gene: PLK1
Genomic location(hg19): chr16:23691404-23701688:+
Genomic location(hg38): chr16:23680083-23690367:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

BC tissues; adjacent normal tissues; xenograft tumors
Cell lines:

BT-549; MDA-MB-231; MCF-10A; HUVECs
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: CXCR4, MMP2, MMP9, Ki67
Associated microRNA: miR-4306
Biological function: promotes breast cancer cell colony formation, proliferation, migration, invasion, metastasis, HUVEC angiogenesis and xenograft tumor formation; inhibits apoptosis
Molecular mechanism: circ_0038632 functions as a ceRNA sponge for miR-4306, thereby upregulating CXCR4 expression and promoting breast cancer progression
Biological pathway or process:

ceRNA regulation (other); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); angiogenesis (promotes); apoptosis (inhibits)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Transfection; Colony Formation Assay; Annexin V/PI Flow Cytometry; Tube Formation Assay; Wound Healing Assay; Transwell Assay; Western Blot; Luciferase Reporter Assay; In Vivo Animal Model; IHC (Immunohistochemistry); Bioinformatics Analysis
Clinical significance:

potential target for breast cancer treatment
Description:

circ_0038632 is up-regulated in breast cancer tissues and cell lines and appears to act as an oncogenic circRNA. It promotes breast cancer cell proliferation, migration, invasion, metastasis, angiogenesis and xenograft tumor growth while suppressing apoptosis. Mechanistically, circ_0038632 sponges miR-4306 to increase CXCR4 expression, forming a circ_0038632/miR-4306/CXCR4 regulatory axis.
Confidence score:

0.7375
Other information
Title:

Circ_0038632 Acts as a Sponge of miR-4306 to Facilitate Breast Cancer Progression Through Regulating CXCR4 Expression.

Journal: Journal of biochemical and molecular toxicology
Published: 2025
PubMed ID: 40227010
Study type:

combined biological and clinical study
Data availability: available from the corresponding author on reasonable request
Code availability: -