circRNA basic information
circBase ID: hsa_circ_0014088
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: Hepatocellular carcinoma / HCC
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

blood exosomes
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DS
Associated gene: MARCH8, SH3PXD2A
Associated microRNA: hsa-miR-186-5p, hsa-miR-613
Biological function: Identified as an exosomal hub biomarker in HCC ceRNA network (no experimental functional validation reported).
Molecular mechanism: ceRNA network construction with predicted miRNA binding for circRNAs.
Biological pathway or process:

ceRNA regulation (other)
Detected method:
M
Validation methods:

Microarray; Bioinformatics Analysis
Clinical significance:

Identified as a hub biomarker in exosomal transcriptome for HCC (prognostic prediction claimed at study level, but no circRNA-specific survival/ROC shown).
Description:

This study identified has-circ-0014088 as a hub circRNA in an exosomal ceRNA network distinguishing HCC from normal samples, based on database-derived differential expression and predicted miRNA binding. No experimental validation or functional assays for this circRNA were reported.
Confidence score:

0.1768
Other information
Title:

Bioinformatics Study Revealed Significance of Exosome Transcriptome in Hepatocellular Carcinoma Diagnosis.

Journal: Frontiers in cell and developmental biology
Published: 2022
PubMed ID: 35573701
Study type:

bioinformatics study
Data availability: https://www.frontiersin.org/articles/10.3389/fcell.2022.813701/full#supplementary-material
Code availability: -