circRNA basic information
circBase ID: hsa_circ_0001727
Name: hsa_circ_ZKSCAN1
Synonym: circZKSCAN1
Host Gene: ZKSCAN1
Genomic location(hg19): chr7:99621041-99621930:+
Genomic location(hg38): chr7:100023418-100024307:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005580
MONDO name: esophageal squamous cell carcinoma
Disease details: esophageal squamous cell carcinoma
Disease DO ID:
 3748
Disease MeSH ID:
 C562729; D000077277
Disease NCIt ID:
 C4024
Disease ICD11 ID:
 1417891145
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

ESCC tissues; normal tissues; matched adjacent normal tissues; metastatic lymph nodes
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DS
Associated gene: -
Associated microRNA: -
Biological function: Potential oncogenic or suppressive role in ESCC progression and metastasis.
Molecular mechanism: Predicted participation in a circRNA-miRNA-mRNA ceRNA network associated with ESCC metastasis.
Biological pathway or process:

ceRNA regulation (other); Wnt/beta-catenin (other); MAPK (other); proliferation (other); stemness (other); metastasis (other)
Detected method:
M
Validation methods:

Microarray; Bioinformatics Analysis
Clinical significance:

Potential biomarker or therapeutic target in ESCC metastasis.
Description:

hsa_circ_0001727 was identified as a dysregulated circRNA in ESCC and metastatic lymph node datasets. The study included it in a predicted metastasis-associated ceRNA network but did not report individual experimental validation for this circRNA.
Confidence score:

0.1768
Other information
Title:

Identification of Metastasis-Associated circRNA-miRNA-mRNA Network Reveals Novel Biomarkers and Therapy Strategies for Esophageal Cancer.

Journal: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
Published: 2026
PubMed ID: 41494978
Study type:

bioinformatics study
Data availability: GSE131969; GSE150476; GSE157805; GSE182090; TCGA
Code availability: -