| Expression pattern: |
UP |
| Associated gene: |
TRIM14 |
| Associated microRNA: |
miR-186-5p |
| Biological function: |
promotes ox-LDL-induced CMEC injury by suppressing proliferation and angiogenesis and promoting apoptosis |
| Molecular mechanism: |
ceRNA mechanism: circ_ROBO2 sponges miR-186-5p to positively regulate TRIM14 |
| Biological pathway or process: |
proliferation (inhibits); apoptosis (promotes); angiogenesis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Western Blot; Nuclear-Cytoplasmic Fractionation; RNase R Treatment; Actinomycin D / DRB Stability Assay; Transfection; EdU Staining; CCK8; Annexin V/PI Flow Cytometry; Tube Formation Assay; Luciferase Reporter Assay; RNA Pull-Down; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
circ_ROBO2 was upregulated in serum of CAD patients versus healthy controls |
| Description: |
circ_ROBO2 is up-regulated in CAD patient serum and in ox-LDL-treated human CMECs. It mainly localizes to the cytoplasm and promotes ox-LDL-induced endothelial injury by sponging miR-186-5p to increase TRIM14, thereby reducing proliferation/angiogenesis and increasing apoptosis. |
| Confidence score: |
0.8119 |