| Expression pattern: |
DN |
| Associated gene: |
ESR1, ERalpha, SMAD7 |
| Associated microRNA: |
hsa-miR-96-5p |
| Biological function: |
hsa_circ_0004913 is described as a key regulator in the ERalpha/circRNA/miRNA/SMADs network; ESR1/ERalpha increases hsa_circ_0004913 expression, and hsa_circ_0004913 targets hsa-miR-96-5p within a network proposed to suppress HCC progression. |
| Molecular mechanism: |
ERalpha/ESR1 functions as a transcription factor binding the hsa_circ_0004913 promoter and enhances its expression; hsa_circ_0004913 interacts with hsa-miR-96-5p in a circRNA/miRNA/SMADs regulatory network involving SMAD7. |
| Biological pathway or process: |
ceRNA regulation (other); TGF-beta/SMAD (other); proliferation (inhibits); migration (inhibits); cell cycle (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Bioinformatics Analysis; Transfection; ChIP / ChIP-seq; Luciferase Reporter Assay |
| Clinical significance: |
- |
| Description: |
In this study, hsa_circ_0004913 was down-regulated in the HCC cell line MHCC97H compared with normal QSG7701 liver cells. ERalpha/ESR1 was shown to bind the hsa_circ_0004913 promoter and increase its expression, while hsa_circ_0004913 interacted with hsa-miR-96-5p within the proposed ERalpha/hsa_circ_0004913/hsa-miR-96-5p/SMAD7 regulatory axis. The authors propose that this circRNA/miRNA/SMADs network contributes to suppression of HCC progression. |
| Confidence score: |
0.5608 |