circRNA basic information
circBase ID: hsa_circ_0005325
Name: hsa_circ_UBA2
Synonym: -
Host Gene: UBA2
Genomic location(hg19): chr19:34921480-34925873:+
Genomic location(hg38): chr19:34430575-34434968:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004958
MONDO name: oral cavity squamous cell carcinoma
Disease details: oral squamous cell carcinoma / OSCC
Disease DO ID:
 0050866
Disease MeSH ID:
 -
Disease NCIt ID:
 C4833
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

OSCC tumor tissues; normal tissues; paired normal tissues
Cell lines:

SCC25; CAL-27; HOK; HUVECs
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: HMGA2, AGO2
Associated microRNA: miR-433-3p
Biological function: promotes proliferation, colony formation, migration, and angiogenesis; inhibits apoptosis in OSCC
Molecular mechanism: Acts as a miRNA sponge (ceRNA) for miR-433-3p to regulate HMGA2 expression
Biological pathway or process:

proliferation (promotes); apoptosis (inhibits); migration (promotes); angiogenesis (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Tube Formation Assay; Annexin V/PI Flow Cytometry; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Western Blot; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0005325 is up-regulated in OSCC tumor tissues and OSCC cell lines and functions as an oncogenic circRNA. It promotes proliferation, colony formation, migration and angiogenesis while inhibiting apoptosis, mainly by sponging miR-433-3p to relieve repression of HMGA2.
Confidence score:

0.705
Other information
Title:

Hsa_circ_0005325 Regulates the Proliferation, Apoptosis, Colony Formation, Migration, and Angiogenesis-Promoting Behavior of Oral Squamous Cell Carcinoma Cells Through the miR-433-3p/HMGA2 Axis.

Journal: Clinical and experimental dental research
Published: 2025
PubMed ID: 40900300
Study type:

combined biological and clinical study
Data availability: Data supporting this study are available from the corresponding author upon request.
Code availability: -