| Expression pattern: |
UP |
| Associated gene: |
ZEB1 |
| Associated microRNA: |
miR-582-5p |
| Biological function: |
Promotes CRC cell proliferation, migration, invasion, metastasis, tumor formation and tumor growth; circ_001860 knockdown suppresses malignant phenotype and tumorigenesis. |
| Molecular mechanism: |
Exosomal circ_001860 acts through a ceRNA mechanism by competitively binding miR-582-5p and increasing ZEB1 expression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
May offer non-invasive biomarkers for clinical screening and diagnosis of CRC patients. |
| Description: |
Exosomal circ_001860 is up-regulated in serum/plasma-derived exosomes from CRC patients and in CRC cell-derived exosomes. It promotes CRC progression by sponging miR-582-5p to enhance ZEB1 expression, thereby increasing cell proliferation, migration, invasion, metastasis, tumor formation and tumor growth. Its exosomal enrichment suggests potential value as a non-invasive biomarker for CRC screening and diagnosis. |
| Confidence score: |
0.6536 |