| Expression pattern: |
UP |
| Associated gene: |
C-Caspase3, Bcl-2 |
| Associated microRNA: |
miR-1205, miR-135-5p, miR-17-3p, miR-2115-5p, miR-3120-5p |
| Biological function: |
Downregulation of circ-ARHGAP26 inhibits proliferation and promotes apoptosis in gastric cancer cells. |
| Molecular mechanism: |
Predicted to regulate target miRNAs (PBM analysis in TSCD), potentially acting via a miRNA sponge-like mechanism; not experimentally validated. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Transfection; CCK8; Annexin V/PI Flow Cytometry; Western Blot |
| Clinical significance: |
- |
| Description: |
circ-ARHGAP26 is up-regulated in multiple gastric cancer cell lines versus normal gastric epithelial cells. Knockdown of circ-ARHGAP26 suppresses proliferation and increases apoptosis (with increased C-Caspase3 and decreased Bcl-2), suggesting an oncogenic role; miRNA targets were predicted but not experimentally validated. |
| Confidence score: |
0.414 |