| Expression pattern: |
UP |
| Associated gene: |
HKDC1, AGO2 |
| Associated microRNA: |
miR-3167, miR-192-3p |
| Biological function: |
Promotes CRC cell proliferation, migration/metastasis, EMT, glycolysis and xenograft tumor growth; inhibits apoptosis and oxidative phosphorylation; reduces chemosensitivity to oxaliplatin. |
| Molecular mechanism: |
circVMP1 acts as a ceRNA that sponges miR-3167, preventing miR-3167-mediated degradation of HKDC1 mRNA and thereby upregulating HKDC1 to activate glycolysis and promote CRC progression. |
| Biological pathway or process: |
glycolysis (promotes); oxidative phosphorylation (inhibits); proliferation (promotes); migration (promotes); metastasis (promotes); EMT (promotes); apoptosis (inhibits); ceRNA regulation (promotes); drug resistance (promotes); chemoresistance (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
Sanger Sequencing; RT-qPCR; RNA-seq; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; In Vivo Animal Model; Western Blot; IHC (Immunohistochemistry); Bioinformatics Analysis |
| Clinical significance: |
circVMP1 might be a therapeutic target that would benefit CRC patients. |
| Description: |
circVMP1 is upregulated in colorectal cancer tissues and functions as a tumor-promoting circRNA. It enhances proliferation, migration/metastasis, EMT, glycolysis and xenograft growth while suppressing apoptosis and reducing oxaliplatin chemosensitivity. Mechanistically, circVMP1 mainly acts through the circVMP1/miR-3167/HKDC1 ceRNA axis to increase HKDC1 expression and activate glycolysis. |
| Confidence score: |
0.8252 |