circRNA basic information
circBase ID: hsa_circ_0009910
Name: hsa_circ_MFN2
Synonym: -
Host Gene: MFN2
Genomic location(hg19): chr1:12049221-12052747:+
Genomic location(hg38): chr1:11989164-11992690:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0100096
MONDO name: COVID-19
Disease details: COVID-19
Disease DO ID:
 0080600
Disease MeSH ID:
 D000086382
Disease NCIt ID:
 -
Disease ICD11 ID:
 1730556128
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

peripheral blood mononuclear cells (PBMCs); blood samples
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: IFNB1
Associated microRNA: hsa-miR-145-5p
Biological function: May participate in COVID-19 immunopathogenesis and innate immune response regulation; may function as a biomarker and therapeutic target in COVID-19 patients.
Molecular mechanism: ceRNA mechanism in which hsa_circ_0009910 may sponge hsa-miR-145-5p and regulate IFNB1-associated immune pathways.
Biological pathway or process:

ceRNA regulation (other); immune regulation (promotes); inflammation (promotes); other pathway/process (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

hsa_circ_0009910 might be a useful biomarker to distinguish COVID-19 patients from healthy controls and may be considered a therapeutic target.
Description:

hsa_circ_0009910 was up-regulated in PBMCs from symptomatic and nonsymptomatic COVID-19 patients compared with negative controls. The study suggests that hsa_circ_0009910 may act through a hsa-miR-145-5p/IFNB1 ceRNA axis involved in COVID-19 immune responses and may have biomarker and therapeutic-target potential.
Confidence score:

0.459
Other information
Title:

Hsa_circ_0009910/hsa-miR-145-5p/IFNB1 Axis Potential Role in the Immunopathogenesis of COVID-19 Disease.

Journal: Genetic testing and molecular biomarkers
Published: 2025
PubMed ID: 41474129
Study type:

combined biological and clinical study
Data availability: All data will be available from the corresponding author, upon reasonable request.
Code availability: -