| Expression pattern: |
UP |
| Associated gene: |
FOXO3 mRNA, Foxo3 protein |
| Associated microRNA: |
- |
| Biological function: |
CircFoxo3 acts as an oncogenic factor in gastric cancer by promoting GC cell proliferation, migration, and in vivo tumor growth; circFoxo3 knockdown inhibits these malignant phenotypes. |
| Molecular mechanism: |
CircFoxo3 promotes gastric cancer progression by regulating Foxo3/FOXO3 expression; circFoxo3 knockdown decreases FOXO3 mRNA and protein levels. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Wound Healing Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
CircFoxo3 could serve as a new treatment target and a promising biomarker for gastric cancer. |
| Description: |
CircFoxo3 is upregulated in gastric cancer tissues and cell lines and functions as an oncogenic circRNA. Its knockdown suppresses GC cell proliferation, migration, and xenograft tumor growth, at least partly by decreasing Foxo3/FOXO3 mRNA and protein expression. The study suggests circFoxo3 may be a therapeutic target and potential biomarker in gastric cancer. |
| Confidence score: |
0.6194 |