| Expression pattern: |
UP |
| Associated gene: |
target mRNAs |
| Associated microRNA: |
miR-185-3p |
| Biological function: |
May play a crucial role in the pathophysiological process of residual cancer transplantation tumors after incomplete RFA; specific functional effects were not experimentally tested. |
| Molecular mechanism: |
ceRNA mechanism involving binding to hsa-miR-185-3p and predicted target mRNAs |
| Biological pathway or process: |
ceRNA regulation (other); other pathway/process (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Luciferase Reporter Assay; Bioinformatics Analysis; In Vivo Animal Model; H&E Staining |
| Clinical significance: |
May provide new directions for investigating molecular mechanisms underlying RFA-treated LC and possible treatment ideas through regulation of circRNAs. |
| Description: |
hsa_circRNA_103595 was up-regulated in incomplete RFA-treated HepG2 xenograft liver cancer tumors and validated by qPCR. The study further confirmed that hsa-miR-185-3p binds hsa_circRNA_103595 by dual-luciferase assay and proposed a ceRNA regulatory network involving predicted target mRNAs. |
| Confidence score: |
0.5495 |