circRNA basic information
circBase ID: hsa_circ_0004277
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr10:1125950-1126416:+
Genomic location(hg38): chr10:1080010-1080476:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma / HCC
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

serum / peripheral blood
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: IL-6, NF-kappaB
Associated microRNA: -
Biological function: Diagnostic biomarker potential for HCV-induced HCC
Molecular mechanism: Bioinformatics-predicted circRNA-miRNA-mRNA network (not experimentally validated)
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

ROC analysis performed to discriminate study groups; mentioned as having diagnostic potential for G3 (HCV-HCC)
Description:

Serum hsa_circ_0004277 is up-regulated in HCV-induced HCC and in HCC compared with controls, and it is evaluated by ROC analysis with diagnostic potential reported for the HCV-HCC group. The study additionally built a predicted circRNA-miRNA-mRNA network for this circRNA, without experimental validation of specific interactors.
Confidence score:

0.459
Other information
Title:

Identification of Serum-Derived CricRNA Diagnostic Panel and Revealing Their Regulatory Mechanisms in HCV-HCC: A Cross-Sectional Study.

Journal: Health science reports
Published: 2024
PubMed ID: 39698527
Study type:

combined biological and clinical study
Data availability: Research data are not shared. it can be shared upon suitable request.
Code availability: -