circRNA basic information
circBase ID: hsa_circ_0003227
Name: hsa_circ_NUP155
Synonym: hsa_ circ_0003227
Host Gene: NUP155
Genomic location(hg19): chr5:37301538-37303516:-
Genomic location(hg38): chr5:37301436-37303414:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

MCF-10A; MCF-7; BT-20
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Potential diagnostic biomarker for breast cancer; expression decreases from normal breast cells to tumorigenic and metastatic breast cancer cell lines.
Molecular mechanism: Not experimentally determined in this study.
Biological pathway or process:

not specified (other)
Detected method:
Q
Validation methods:

RT-qPCR
Clinical significance:

Potential early diagnostic biomarker for breast cancer; monitoring expression may help early detection and disease progression tracking, but clinical validation is still required.
Description:

hsa_circ_0003227 was experimentally measured by RT-qPCR in MCF-10A, BT-20, and MCF-7 cells and was significantly down-regulated in breast cancer and metastatic cell lines compared with normal breast epithelial cells. The study proposes it as a potential diagnostic biomarker for breast cancer, but its molecular mechanism and clinical performance were not validated.
Confidence score:

0.1155
Other information
Title:

Study the Expression of Two Circular RNAs, hsa_circ_0003227 and hsa_circ_0001666, in the Primary Breast Cancer Cell Line BT-20 and the Metastatic Breast Cancer Cell Line MCF-7.

Journal: Biochemical genetics
Published: 2026
PubMed ID: 39976889
Study type:

biological research
Data availability: -
Code availability: -