| Expression pattern: |
UP |
| Associated gene: |
PDIA6 mRNA, PDIA6 |
| Associated microRNA: |
- |
| Biological function: |
circSETD3 promotes nasopharyngeal carcinoma radioresistance, enhances NPC cell survival and proliferation under radiation stress, and suppresses radiation-induced autophagy and apoptosis. |
| Molecular mechanism: |
circSETD3 directly binds to the 3′UTR of PDIA6 mRNA, stabilizes PDIA6 mRNA, increases PDIA6 protein expression and ER localization, maintains ER proteostasis, suppresses UPR/ER stress, and reduces radiation-induced autophagy and apoptosis. |
| Biological pathway or process: |
radioresistance (promotes); autophagy (inhibits); apoptosis (inhibits); proliferation (promotes); mRNA stability (promotes); other pathway/process (inhibits) |
| Detected method: |
Q
H
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; Colony Formation Assay; MTT; In Vivo Animal Model; H&E Staining; ISH (In Situ Hybridization); IHC (Immunohistochemistry); IF (Immunofluorescence); TUNEL; Western Blot; Bioinformatics Analysis; RNA Pull-Down; circRIP; Luciferase Reporter Assay; Actinomycin D / DRB Stability Assay |
| Clinical significance: |
circSETD3 is highly expressed in NPC tissues, correlated with poor patient prognosis, and may serve as a predictive biomarker for radiotherapy response and a therapeutic target for radiosensitization. |
| Description: |
circSETD3 acts as a pro-radioresistance circRNA in nasopharyngeal carcinoma. It binds the 3′UTR of PDIA6 mRNA to enhance PDIA6 mRNA stability and protein expression, thereby maintaining ER proteostasis, suppressing UPR/ER stress, and inhibiting radiation-induced autophagy and apoptosis. The circSETD3-PDIA6 axis is proposed as a potential therapeutic target and predictive biomarker for radiotherapy response. |
| Confidence score: |
0.8325 |