| Expression pattern: |
UP |
| Associated gene: |
PKP3 |
| Associated microRNA: |
miR-328-5p |
| Biological function: |
Promotes NSCLC tumor progression, cellular proliferation, migration, invasion, dissemination, and tumorigenesis in vitro. |
| Molecular mechanism: |
circFOXK2 functions as a ceRNA and molecular sponge for miR-328-5p, thereby upregulating PKP3 expression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Wound Healing Assay |
| Clinical significance: |
The circFOXK2/miR-328-5p/PKP3 signaling axis is identified as a potential therapeutic target in NSCLC. |
| Description: |
circFOXK2 is up-regulated in NSCLC tissues and cell lines. It promotes NSCLC cell proliferation, migration, invasion, and tumorigenic progression in vitro by sponging miR-328-5p and indirectly increasing PKP3 expression. The circFOXK2/miR-328-5p/PKP3 axis is proposed as a potential therapeutic target for NSCLC. |
| Confidence score: |
0.6521 |