| Expression pattern: |
DN |
| Associated gene: |
PDCD4, CASC3, MTDH |
| Associated microRNA: |
miR-149-5p, miR-330-3p, miR-452-5p |
| Biological function: |
Promotes apoptosis and inhibits proliferation, migration, invasion, and tumor growth/metastasis in breast cancer. |
| Molecular mechanism: |
circ-NOL10 is repressed by RBPs (MTDH/CASC3) and acts as a miRNA sponge for miR-149-5p/miR-330-3p/miR-452-5p to de-repress PDCD4, thereby promoting apoptosis and suppressing malignant phenotypes. |
| Biological pathway or process: |
apoptosis (promotes); proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; FISH / smFISH; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Wound Healing Assay; Transwell Assay; Colony Formation Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model; Clinical Sample Validation; Cohort Study; Survival Analysis; ROC Analysis; Bioinformatics Analysis; IF (Immunofluorescence) |
| Clinical significance: |
Low circ-NOL10 expression is associated with aggressive characteristics and shorter DFS/OS; circ-NOL10 shows diagnostic potential (ROC AUC ~0.92 in TNBC). |
| Description: |
circ-NOL10 is down-regulated in breast cancer (notably TNBC) and functions as a tumor suppressor by promoting apoptosis and inhibiting proliferation, migration, invasion and xenograft tumor growth. Mechanistically, it is repressed by the RBPs MTDH and CASC3 and sponges miR-149-5p/miR-330-3p/miR-452-5p to upregulate the tumor suppressor PDCD4; low circ-NOL10 is associated with poorer patient outcomes and has diagnostic potential. |
| Confidence score: |
0.8072 |