| Expression pattern: |
DN |
| Associated gene: |
EOMES, STAT4, ETS1, JUN, MITF, CD38, Q9NR56, P35637, Q8TB72, Q96MU7, MBNL1, FUS, PUM2, YTDC1 |
| Associated microRNA: |
- |
| Biological function: |
CircRSF1 may serve as a diagnostic biomarker for pSS and may regulate immune pathways through miRNA sponge activity, predicted miRNA-mRNA networks, protein binding, and m6A-related mechanisms. |
| Molecular mechanism: |
Predicted ceRNA/miRNA sponge mechanism involving CircRSF1-miRNA-mRNA regulation; predicted direct binding to RNA-binding proteins/proteins; predicted m6A modification sites. |
| Biological pathway or process: |
ceRNA regulation (other); immune regulation (other); MAPK (other); p53 signaling (other); PI3K/AKT (other); AMPK (other); apoptosis (other); autophagy (other); m6A modification (other); inflammation (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RT-qPCR; RNA-seq; RNase R Treatment; Sanger Sequencing; FISH / smFISH; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis; Back-Splice Junction PCR / divergent primers PCR |
| Clinical significance: |
CircRSF1 may serve as a novel potential diagnostic biomarker for pSS and showed diagnostic specificity for pSS compared with SLE and RA. |
| Description: |
CircRSF1 is a human circRNA derived from RSF1 that is significantly down-regulated in PBMCs and LSGs from pSS patients. The study supports its potential as a pSS-specific diagnostic biomarker and predicts that it may function through cytoplasmic miRNA sponge activity, CircRSF1-miRNA-mRNA regulation, protein/RBP interactions, and m6A-related mechanisms affecting immune and inflammatory pathways. |
| Confidence score: |
0.6981 |