circRNA basic information
circBase ID: hsa_circ_0001900
Name: hsa_circ_CAMSAP1
Synonym: circCAMSAP1
Host Gene: CAMSAP1
Genomic location(hg19): chr9:138773478-138774924:-
Genomic location(hg38): chr9:135881633-135883078:.
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0006058
MONDO name: Wilms tumor
Disease details: Wilms tumor
Disease DO ID:
 -
Disease MeSH ID:
 D009396
Disease NCIt ID:
 C3267
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

Wilms tumor tissue; paired normal tissue; adjacent control tissue
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: CAMSAP1
Associated microRNA: -
Biological function: Potential association with Wilms tumor progression; high expression correlates with larger tumor volume and poorer recurrence-free survival trend.
Molecular mechanism: Back-spliced circular RNA derived from exons 2 and 3 of CAMSAP1; no disease-related molecular mechanism was experimentally defined.
Biological pathway or process:

not specified
Detected method:
Q
S
Validation methods:

Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; circRNA-seq; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis; Survival Analysis; Cohort Study
Clinical significance:

Tumor-specific high expression; diagnostic ROC AUC 0.72; expression positively correlated with tumor volume; high-expression group showed lower recurrence-free survival trend.
Description:

This study identified hsa_circ_0001900, also referred to as circCAMSAP1, as a tumor-specifically up-regulated circular RNA in Wilms tumor. Its expression was validated in clinical samples, correlated positively with tumor volume, showed diagnostic potential by ROC analysis, and was associated with a trend toward poorer recurrence-free survival.
Confidence score:

0.7137
Other information
Title:

[High-throughput circular RNA sequencing reveals tumor-specific high expression of hsa_circ_0001900 in Wilms tumor in association with poor prognosis].

Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University
Published: 2025
PubMed ID: 41311088
Study type:

combined biological and clinical study
Data availability: -
Code availability: -