circRNA basic information
circBase ID: hsa_circ_0001789
Name: hsa_circ_RAB11FIP1
Synonym: circRCP
Host Gene: -
Genomic location(hg19): chr8:37734626-37735069:-
Genomic location(hg38): chr8:37877108-37877551:-
Subcellular localization: cytoplasm; mitochondria
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005611
MONDO name: bladder transitional cell carcinoma
Disease details: urothelial carcinoma of the bladder
Disease DO ID:
 4006
Disease MeSH ID:
 -
Disease NCIt ID:
 C39851
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

UCB tissues; matched adjacent normal tissues; matched non-tumor tissues; patient-derived UCB organoids
Cell lines:

T24; 5637; TCC-SUP; J82; RT4; UM-UC-3; SV-HUC-1
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: LRPPRC, SLIRP, mt-ND1, mt-ND2, mt-ND3, mt-ND4, mt-ND4L, mt-ND5, mt-ND6, mt-CO1, mt-CO2, mt-CO3, mt-CYB, mt-ATP6, mt-ATP8, FOXM1, PRDX3, MnSOD, Catalase
Associated microRNA: -
Biological function: Promotes UCB tumorigenesis, cell proliferation, colony formation, mitochondrial function and redox homeostasis, while inhibiting intrinsic apoptosis and oxidative stress-induced ROS accumulation.
Molecular mechanism: circRCP acts as an RNA-protein scaffold that forms a circRCP/LRPPRC/SLIRP ternary complex, stabilizes the LRPPRC/SLIRP complex, inhibits LRPPRC ubiquitination and proteasomal degradation, regulates mitochondrial mRNA metabolism and mitochondrial redox homeostasis.
Biological pathway or process:

proliferation (promotes); apoptosis (inhibits); oxidative phosphorylation (promotes); mitochondrial function (promotes); ubiquitination (inhibits); mRNA stability (promotes); other pathway/process (promotes)
Detected method:
Q
M
Validation methods:

Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; Actinomycin D / DRB Stability Assay; RT-qPCR; Microarray; FISH / smFISH; IF (Immunofluorescence); Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); RNA Pull-Down; Co-IP; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Flow Cytometry（Non-apoptosis/cycle）; IHC (Immunohistochemistry); In Vivo Animal Model; Western Blot; Cohort Study; Survival Analysis; Bioinformatics Analysis
Clinical significance:

circRCP overexpression serves as an independent prognostic factor for poor survival in UCB patients; high co-expression of circRCP and LRPPRC predicts the poorest OS and may serve as a diagnostic/prognostic biomarker and therapeutic target.
Description:

circRCP is a human RAB11FIP1-derived circRNA that is frequently upregulated in UCB and predicts poor survival. It promotes UCB tumorigenesis by localizing predominantly to mitochondria and stabilizing the LRPPRC/SLIRP complex, thereby maintaining mitochondrial mRNA metabolism, oxidative phosphorylation, redox homeostasis and resistance to intrinsic apoptosis.
Confidence score:

0.8981
Other information
Title:

Mitochondria-located circRCP regulates redox homeostasis via stabilizing LRPPRC/SLIRP complex to promote bladder urothelial carcinoma tumorigenesis.

Journal: Cancer letters
Published: 2026
PubMed ID: 41274398
Study type:

combined biological and clinical study
Data availability: GSE243127; Supplementary Data 1; Supplementary Table 1; Supplementary Table 2; Supplementary Table 3; https://doi.org/10.1016/j.canlet.2025.218157
Code availability: -