| Expression pattern: |
UP |
| Associated gene: |
CCND1 |
| Associated microRNA: |
miR-502-5p |
| Biological function: |
promotes proliferation, migration and invasion, and inhibits apoptosis of HCC cells |
| Molecular mechanism: |
circ_0008092 acts as a miR-502-5p sponge and up-regulates CCND1 expression, promoting HCC progression through the circ_0008092/miR-502-5p/CCND1 axis |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; Western Blot; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
high circ_0008092 expression was associated with shorter overall survival in HCC patients and may be a potential target for HCC therapy |
| Description: |
circ_0008092 is up-regulated in HCC tissues, cells, and plasma datasets, and high expression is associated with shorter overall survival. Functionally, it promotes HCC cell proliferation, migration and invasion while inhibiting apoptosis. Mechanistically, circ_0008092 acts as a miR-502-5p sponge to indirectly up-regulate CCND1 through the circ_0008092/miR-502-5p/CCND1 axis. |
| Confidence score: |
0.7941 |