circRNA basic information
circBase ID: hsa_circ_0081143
Name: hsa_circ_COL1A2
Synonym: -
Host Gene: COL1A2
Genomic location(hg19): chr7:94044537-94055169:+
Genomic location(hg38): chr7:94415225-94425857:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: Gastric cancer
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

GC tissues; adjacent nontumor gastric tissues
Cell lines:

AGS; HGC-27; GES-1
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: EGFR
Associated microRNA: miR-497-5p
Biological function: circ_0081143 promotes hypoxia-induced migration, invasion, and EMT in gastric cancer cells; knockdown of circ_0081143 mitigates these malignant behaviors.
Molecular mechanism: circ_0081143 acts as a competing endogenous RNA by sponging miR-497-5p, thereby modulating EGFR expression in hypoxia-induced gastric cancer cells.
Biological pathway or process:

migration (promotes); invasion (promotes); EMT (promotes); ceRNA regulation (promotes); EGFR (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; Transwell Assay; Western Blot
Clinical significance:

Target circ_0081143 might be a promising therapeutic strategy for GC management.
Description:

circ_0081143 is up-regulated in gastric cancer tissues and cells and is further induced by hypoxia in GC cells. Functionally, circ_0081143 promotes hypoxia-induced migration, invasion, and EMT, while its knockdown suppresses these malignant behaviors. Mechanistically, circ_0081143 acts as a ceRNA for miR-497-5p to modulate EGFR expression, suggesting therapeutic potential in GC.
Confidence score:

0.6369
Other information
Title:

Knockdown of Circ_0081143 Mitigates Hypoxia-Induced Migration, Invasion, and EMT in Gastric Cancer Cells Through the miR-497-5p/EGFR Axis.

Journal: Cancer biotherapy & radiopharmaceuticals
Published: 2021
PubMed ID: 32678674
Study type:

combined biological and clinical study
Data availability: The analyzed data sets generated during the present study are available from the corresponding author on reasonable request.
Code availability: -