| Expression pattern: |
UP |
| Associated gene: |
ATG7 |
| Associated microRNA: |
miR-129-5p |
| Biological function: |
Promotes inflammatory responses and autophagy during gout (including recurrence) by increasing ATG7 and inflammatory cytokine production. |
| Molecular mechanism: |
ceRNA mechanism: circ_0058051 sponges miR-129-5p, relieving repression of ATG7, thereby promoting ATG7-mediated autophagy and inflammatory cytokine release. |
| Biological pathway or process: |
autophagy (promotes); inflammation (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; Western Blot; ELISA |
| Clinical significance: |
circ_0058051 is higher in gout patients than healthy controls, and higher during attack and recurrence than stable/first attack stages; proposed as a therapeutic target to prevent recurrence. |
| Description: |
circ_0058051 is up-regulated in PBMCs from gout patients, especially during attack and recurrence. It promotes gouty inflammatory responses by acting as a ceRNA that sponges miR-129-5p, thereby increasing ATG7 and enhancing ATG7-mediated autophagy and pro-inflammatory cytokine production in MSU-stimulated macrophages. |
| Confidence score: |
0.6369 |