| Expression pattern: |
UN |
| Associated gene: |
KLF4, MYC, CCNA2, RACGAP1, CD44 |
| Associated microRNA: |
hsa-miR-29a-3p |
| Biological function: |
Potentially participates in CRC development by acting in a ceRNA axis with hsa-miR-29a-3p and KLF4, affecting proliferation and possibly invasion/metastasis and genomic stability (as hypothesized). |
| Molecular mechanism: |
Proposed ceRNA/miRNA sponge mechanism involving hsa-miR-29a-3p with downstream KLF4 regulation. |
| Biological pathway or process: |
ceRNA regulation (other); proliferation (other); invasion (other); metastasis (other); Wnt/beta-catenin (other); Hippo/YAP (other); EMT (other) |
| Detected method: |
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; Survival Analysis; ROC Analysis |
| Clinical significance: |
Identified in a ceRNA sub-network with potential regulatory effect on survival-related genes; proposed as potential diagnostic/prognostic biomarker pending experimental validation. |
| Description: |
This study identifies hsa_circ_0071681 in an in-silico ceRNA sub-network, proposing it sponges hsa-miR-29a-3p to affect KLF4 and related survival-associated hub genes in CRC. The mechanistic and clinical implications are computationally inferred and require experimental validation. |
| Confidence score: |
0.459 |