circRNA basic information
circBase ID: -
Name: rno_circ_CDR1
Synonym: ciRs-7
Host Gene: CDR1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004975
MONDO name: Alzheimer disease
Disease details: Alzheimer's disease
Disease DO ID:
 10652
Disease MeSH ID:
 D000544
Disease NCIt ID:
 C2866
Disease ICD11 ID:
 1611724421
Disease OMIM ID:
 -
Species: Rat
Species details: Rattus norvegicus
Tissue specimen:

hippocampal tissue
Cell lines:

PC12
In vivo animal model:

other disease animal model
circRNA-disease information
Expression pattern:
DN
Associated gene: UBE2A, Abeta1-42
Associated microRNA: miR-7
Biological function: ciRs-7 overexpression mitigates aluminum maltol-induced neurotoxicity, reduces miR-7 expression and Abeta1-42 accumulation, and increases UBE2A expression.
Molecular mechanism: ciRs-7 acts as a miR-7 sponge; aluminum exposure downregulates ciRs-7, derepresses miR-7, suppresses UBE2A expression, and promotes Abeta deposition.
Biological pathway or process:

ceRNA regulation (promotes); ubiquitination (promotes); other pathway/process (inhibits)
Detected method:
Q
Validation methods:

RT-qPCR; Transfection; Western Blot; ELISA; In Vivo Animal Model
Clinical significance:

suggesting therapeutic targets for AD intervention
Description:

This study identifies ciRs-7 as a down-regulated circRNA in aluminum-induced neurotoxicity models. Reduced ciRs-7 releases miR-7 activity, leading to decreased UBE2A expression and increased Abeta deposition, while ciRs-7 overexpression reverses these pathological changes and mitigates cellular injury.
Confidence score:

0.414
Other information
Title:

Aluminum Exposure Leads to Abeta Deposition via the ciRs-7 Pathway.

Journal: Biological trace element research
Published: 2026
PubMed ID: 41199071
Study type:

biological research
Data availability: No datasets were generated or analysed during the current study.
Code availability: -