| Expression pattern: |
UP |
| Associated gene: |
PRKCA, p38, p-p38 |
| Associated microRNA: |
miR-545-3p |
| Biological function: |
Promotes NSCLC tumorigenesis, proliferation and invasion, and inhibits apoptosis. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-545-3p, relieving repression of PRKCA and activating p38/MAPK signaling. |
| Biological pathway or process: |
MAPK (promotes); p38/MAPK (promotes); proliferation (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Bioinformatics Analysis; Transfection; CCK8; Transwell Assay; Annexin V/PI Flow Cytometry; FISH / smFISH; RNA Pull-Down; Luciferase Reporter Assay; Western Blot; In Vivo Animal Model; Survival Analysis |
| Clinical significance: |
Hsa_circ_0007580 was upregulated in NSCLC tumor tissues. |
| Description: |
hsa_circ_0007580 is up-regulated in NSCLC and promotes tumorigenesis. Functionally, its knockdown suppresses proliferation and invasion and induces apoptosis in NSCLC cells and xenografts. Mechanistically, hsa_circ_0007580 sponges miR-545-3p to derepress PRKCA and activate p38/MAPK signaling. |
| Confidence score: |
0.7415 |