| Expression pattern: |
UP |
| Associated gene: |
PFKFB3, MDR1, HK2, LDHA |
| Associated microRNA: |
miR-545-3p |
| Biological function: |
CircSAMD4A promotes 5-Fu resistance, cell viability, proliferation, glycolysis and tumor growth, and inhibits apoptosis in 5-Fu-resistant colorectal cancer. |
| Molecular mechanism: |
CircSAMD4A acts as a ceRNA/molecular sponge for miR-545-3p to upregulate PFKFB3 expression, thereby enhancing glycolysis and 5-Fu resistance in CRC. |
| Biological pathway or process: |
ceRNA regulation (promotes); glycolysis (promotes); proliferation (promotes); apoptosis (inhibits); drug resistance (promotes); chemoresistance (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis; RNA Pull-Down; Luciferase Reporter Assay; Transfection; MTT; EdU Staining; Colony Formation Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
High circSAMD4A expression is associated with lower 5-year overall survival and may be a therapeutic target for 5-Fu resistance in CRC. |
| Description: |
CircSAMD4A is up-regulated in 5-Fu-resistant colorectal cancer tissues and cells and is associated with poorer 5-year overall survival. It promotes 5-Fu resistance, proliferation, glycolysis, and tumor growth while suppressing apoptosis by sponging miR-545-3p and up-regulating PFKFB3. |
| Confidence score: |
0.8353 |