circRNA basic information
circBase ID: hsa_circ_0001445
Name: hsa_circ_SMARCA5
Synonym: cSMARCA5
Host Gene: SMARCA5
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

liver tissue; whole blood; peripheral venous blood
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Serves as a clinically accessible liquid biopsy biomarker for HCC screening; its expression is lower in HCC tissues and blood from HCC patients than in adjacent noncancerous liver tissues or normal people.
Molecular mechanism: Not specified as a disease mechanism; the study focuses on nanobiosensor-based recognition of the cSMARCA5 back-splice junction through CHA cascade amplification and magnetic control depuration for quantitative detection.
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation
Clinical significance:

Downregulated cSMARCA5 can be used as a biomarker to screen and differentiate HCC patients from normal people in liver tissue and whole blood samples.
Description:

This study developed and clinically validated a CHA cascade amplification and magnetic control depuration nanobiosensor to quantify cSMARCA5 in liver tissue and whole blood. cSMARCA5 was significantly downregulated in HCC tissues and peripheral venous blood from HCC patients, and its measurement could differentiate HCC patients from normal people, supporting its use as a liquid biopsy biomarker for HCC screening.
Confidence score:

0.2995
Other information
Title:

An Ultrasensitive and Robust CircRNA Nanobiosensor via Magnetic Control Depuration and Catalytic Hairpin Assembly Cascade Amplification for Clinically Accessible Liquid Biopsy.

Journal: Analytical chemistry
Published: 2025
PubMed ID: 41123576
Study type:

combined analytical method development and clinical validation study
Data availability: Supporting Information: https://pubs.acs.org/doi/10.1021/acs.analchem.5c03434
Code availability: -