circRNA basic information
circBase ID: -
Name: hsa_circ_SMARCC1
Synonym: circSMARCC1
Host Gene: SMARCC1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: exosome
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissues; matched adjacent non-tumor tissues; peripheral blood; peripheral blood-derived exosomes; tumor tissue samples
Cell lines:

GES-1; HGC27; NCI-N87; SNU-16; AGS; THP-1
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: U2AF2
Associated microRNA: -
Biological function: circSMARCC1 promotes STAD cell proliferation and invasion, tumor growth, and macrophage M2 polarization; circSMARCC1 knockdown suppresses malignant phenotypes and M2 macrophage polarization.
Molecular mechanism: STAD cell-derived exosomes deliver circSMARCC1 to promote macrophage M2 polarization by upregulating U2AF2 expression.
Biological pathway or process:

proliferation (promotes); invasion (promotes); macrophage polarization (promotes); immune regulation (other); other pathway/process (promotes)
Detected method:
Q
M
Validation methods:

RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Survival Analysis; Transfection; CCK8; EdU Staining; Transwell Assay; Western Blot; ELISA; IF (Immunofluorescence); In Vivo Animal Model
Clinical significance:

High circSMARCC1 expression is associated with poor prognosis and decreased overall survival in STAD patients; circulating exosomal circSMARCC1 is increased in STAD patients.
Description:

circSMARCC1 is up-regulated in gastric cancer tissues, cell lines, and circulating exosomes, and high expression is associated with poor survival. Functionally, circSMARCC1 promotes STAD cell proliferation, invasion, tumor growth, and macrophage M2 polarization. Mechanistically, STAD cell-derived exosomes deliver circSMARCC1 to macrophages, where it increases U2AF2 expression and drives M2 polarization to promote STAD progression.
Confidence score:

0.6482
Other information
Title:

Gastric Cancer Cell-Derived Exosomes Induce Macrophage M2 Polarization by Delivering circSMARCC1 to Promote Gastric Cancer Progression.

Journal: IUBMB life
Published: 2025
PubMed ID: 41099193
Study type:

combined biological and clinical study
Data availability: available from the corresponding author upon request; Table S1; Table S2
Code availability: -