| Expression pattern: |
DN |
| Associated gene: |
MTSS1 |
| Associated microRNA: |
miR-182 |
| Biological function: |
Circ_002059 acts as a tumor suppressor in gastric cancer by inhibiting GC cell proliferation, migration, and xenograft tumor growth. |
| Molecular mechanism: |
Circ_002059 upregulates MTSS1 expression by competitively sponging miR-182, thereby inhibiting GC progression. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); ceRNA regulation (promotes); metastasis (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Transfection; MTT; Transwell Assay; Luciferase Reporter Assay; RNA Pull-Down; Western Blot; In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
Lower expression of hsa_circ_002059 was significantly associated with distal metastasis, TNM stage, gender, and age, and may be associated with poor prognosis; circ_002059 may be a potential therapeutic target in GC patients. |
| Description: |
Circ_002059 is down-regulated in gastric cancer contexts and functions as a tumor suppressor. It inhibits GC cell proliferation, migration, and xenograft tumor growth by sponging miR-182 and thereby increasing MTSS1 expression. |
| Confidence score: |
0.6253 |