| Expression pattern: |
UP |
| Associated gene: |
ADAR1, hnRNPA2B1 |
| Associated microRNA: |
miR-548a-3p |
| Biological function: |
FLS-derived exosomal circFTO is elevated in RA-FLSs and RA-FLS-associated cartilage tissues; ADAR1 overexpression downregulates circFTO and is associated with attenuated arthritis severity, cartilage degradation, inflammatory response, migration, and invasion in the SCID-HuRAg RA model. |
| Molecular mechanism: |
ADAR1-mediated regulation of FLS-derived exosomal circFTO, accompanied by decreased hnRNPA2B1 expression and increased miR-548a-3p expression; circFTO is implicated in RA-related inflammation and cartilage degradation. |
| Biological pathway or process: |
inflammation (promotes); migration (promotes); invasion (promotes); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Transfection; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); Western Blot |
| Clinical significance: |
- |
| Description: |
circFTO is an FLS-derived exosomal circRNA that is up-regulated in RA-FLSs and in the RA-FLS SCID-HuRAg model. The study suggests that ADAR1 attenuates RA-associated inflammation and cartilage degradation at least partly by downregulating exosomal circFTO, with associated changes in miR-548a-3p and hnRNPA2B1 expression. |
| Confidence score: |
0.5358 |