circRNA basic information
circBase ID: hsa_circ_0003641
Name: hsa_circ_ATM
Synonym: -
Host Gene: ATM
Genomic location(hg19): chr11:108098321-108106561:+
Genomic location(hg38): chr11:108227594-108235834:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0000548
MONDO name: ovarian clear cell cancer
Disease details: ovarian clear cell carcinoma
Disease DO ID:
 0050934
Disease MeSH ID:
 -
Disease NCIt ID:
 C40077
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

OCCC clinical samples; normal ovarian tissues
Cell lines:

NIHOVCAR3; SKOV3; A293T
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DS
Associated gene: -
Associated microRNA: -
Biological function: Likely functions as a miRNA sponge in an OCCC ceRNA network, modulating downstream mRNAs implicated in tumor progression and immune evasion.
Molecular mechanism: circRNA-miRNA-mRNA ceRNA mechanism based on inversely correlated miRNA-circRNA and mRNA-miRNA interaction pairs.
Biological pathway or process:

ceRNA regulation (other); immune regulation (other); other pathway/process (other)
Detected method:
S
M
Validation methods:

RNA-seq; Microarray; Bioinformatics Analysis
Clinical significance:

Potential clinical relevance for biomarker development and targeted therapy in OCCC.
Description:

hsa_circ_0003641 is a core dysregulated OCCC circRNA derived from the ATM gene. It is incorporated into a predicted circRNA-miRNA-mRNA ceRNA regulatory network associated with oncogenic networks and immune evasion, although the study provides only bioinformatic evidence.
Confidence score:

0.2465
Other information
Title:

Construction of a circRNA-miRNA-mRNA ceRNA regulatory network identifies RNAs and genes linked to human ovarian clear cell carcinoma.

Journal: Archives of biochemistry and biophysics
Published: 2025
PubMed ID: 41015145
Study type:

bioinformatics study
Data availability: GSE271851; GSE266248; GSE230956; GSE200852; TCGA; GTEx; HPA; Supplementary data at https://doi. org/10.1016/j.abb.2025.110623
Code availability: -