circRNA basic information
circBase ID: hsa_circ_0058106
Name: hsa_circ_FN1
Synonym: -
Host Gene: FN1
Genomic location(hg19): chr2:216246934-216248907:-
Genomic location(hg38): chr2:215382211-215384184:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0044638
MONDO name: hypopharynx squamous cell carcinoma
Disease details: hypopharyngeal squamous cell carcinoma
Disease DO ID:
 -
Disease MeSH ID:
 -
Disease NCIt ID:
 C4043
Disease ICD11 ID:
 680629191
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

HSCC tumor tissues; adjacent normal tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: miR-185-3p, miR-4638-3p
Biological function: May inhibit apoptosis and promote proliferation in HSCC by sponging miR-185-3p (speculative).
Molecular mechanism: Predicted miRNA sponge (ceRNA) mechanism via miR-185-3p and miR-4638-3p in circRNA-miRNA-mRNA networks.
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; divergent primers PCR; RNase R Treatment; Bioinformatics Analysis; Clinical Sample Validation
Clinical significance:

-
Description:

hsa_circ_0058106 is up-regulated in HSCC tumor tissues and was validated by qRT-PCR. The study predicts it may act as a miRNA sponge (e.g., miR-185-3p, miR-4638-3p) within circRNA-miRNA-mRNA networks, potentially influencing apoptosis-related behavior, but functional effects were not experimentally tested.
Confidence score:

0.585
Other information
Title:

Novel circular RNA expression profiles reflect progression of patients with hypopharyngeal squamous cell carcinoma.

Journal: Oncotarget
Published: 2017
PubMed ID: 28514762
Study type:

combined biological and clinical study
Data availability: -
Code availability: -