circRNA basic information
circBase ID: hsa_circ_0005918
Name: hsa_circ_FCHSD2
Synonym: -
Host Gene: FCHSD2
Genomic location(hg19): chr11:72695132-72700142:-
Genomic location(hg38): chr11:72695132-72700142:.
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0006337
MONDO name: ovarian endometriosis
Disease details: ovarian endometriosis
Disease DO ID:
 11432
Disease MeSH ID:
 -
Disease NCIt ID:
 C27628
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

paired eutopic and ectopic endometrium; ectopic endometrial tissues; eutopic endometrial tissues; ovarian cyst wall
Cell lines:

EcESCs; EuESCs; HEK-293 T
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: PDLIM2, OBSL1
Associated microRNA: miR-504-5p, miR-105-5p
Biological function: hsa_circ_0005918 promotes migration and invasion of endometrial stromal cells and may contribute to the progression of endometriotic lesions.
Molecular mechanism: ceRNA mechanism: hsa_circ_0005918 sponges miR-504-5p and miR-105-5p, thereby upregulating PDLIM2 and OBSL1.
Biological pathway or process:

migration (promotes); invasion (promotes); ceRNA regulation (promotes)
Detected method:
Q
S
Validation methods:

circRNA-seq; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Transfection; Transwell Assay; Luciferase Reporter Assay; Western Blot
Clinical significance:

-
Description:

hsa_circ_0005918 is up-regulated in ectopic endometrial tissues and ectopic stromal cells from patients with endometriosis. It promotes endometrial stromal cell migration and invasion through ceRNA axes involving miR-504-5p/PDLIM2 and miR-105-5p/OBSL1, suggesting a role in the progression of endometriotic lesions.
Confidence score:

0.704
Other information
Title:

Combination of circular RNA-miRNA-mRNA expression profiles and bioinformatic analysis in ovarian endometriosis.

Journal: Genomics
Published: 2025
PubMed ID: 40962208
Study type:

combined biological and clinical study
Data availability: published article and its supplementary information files; https://doi.org/10.1016/j.ygeno.2025.111112
Code availability: -