circRNA basic information
circBase ID: -
Name: mmu_circ_Cdr1as
Synonym: circ-cdr1as
Host Gene: CDR1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005068
MONDO name: myocardial infarction
Disease details: myocardial infarction
Disease DO ID:
 5844
Disease MeSH ID:
 D009203
Disease NCIt ID:
 C27996
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Mouse
Species details: Mus musculus
Tissue specimen:

mouse hearts; left ventricle heart tissue; LV tissue; ischemic myocardium; injured myocardium; myocardium
Cell lines:

RAW 264.7; RAW264.7; HL-1
In vivo animal model:

other disease animal model
circRNA-disease information
Expression pattern:
DN
Associated gene: KLF4, Klf4
Associated microRNA: microRNA-7, miR-7, miRNA-7, miR-7b-3p, miR-7b-5p
Biological function: Regulates macrophage phenotype toward an anti-inflammatory M2-like reparative phenotype, improves left ventricular function, reduces infarct size, enhances angiogenesis, and reduces cardiomyocyte apoptosis after myocardial infarction.
Molecular mechanism: circ-cdr1as acts as a miR-7 sponge, represses miR-7 activity, prevents repression of the miR-7 target Klf4/KLF4, and thereby promotes anti-inflammatory macrophage polarization during cardiac injury.
Biological pathway or process:

immune regulation (promotes); macrophage polarization (promotes); apoptosis (inhibits); angiogenesis (promotes); inflammation (inhibits); ceRNA regulation (promotes); other pathway/process (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; RNA Pull-Down; Transfection; Flow Cytometry（Non-apoptosis/cycle）; IHC (Immunohistochemistry); IF (Immunofluorescence); TUNEL; In Vivo Animal Model; Bioinformatics Analysis
Clinical significance:

Potential anti-inflammatory therapeutic regulator to improve cardiac repair and post-MI cardiac function.
Description:

In this mouse myocardial infarction study, circ-cdr1as was downregulated in early post-MI hearts, particularly in macrophages and cardiomyocytes. Overexpression of circ-cdr1as promoted anti-inflammatory M2-like macrophage polarization, reduced cardiomyocyte apoptosis and infarct size, enhanced vascularization, and improved cardiac function. Mechanistically, circ-cdr1as sponged miR-7 to relieve repression of Klf4/KLF4, forming a circ-cdr1as/miR-7/Klf4 immune-regulatory axis.
Confidence score:

0.7113
Other information
Title:

Circular RNA Cdr1as Modulates Macrophage-Mediated Cardiac Reparative Function.

Journal: Circulation research
Published: 2025
PubMed ID: 40955561
Study type:

biological research
Data availability: All original data and materials used for this study are available from the corresponding author on reasonable request; Supplemental Material
Code availability: -