| Expression pattern: |
UP |
| Associated gene: |
IL13RA1 |
| Associated microRNA: |
miR-488-3p |
| Biological function: |
Promotes PTC cell proliferation, colony formation, invasion, tumor growth, macrophage migration, and IL13RA1-dependent M2 macrophage polarization; associated with lymph node metastasis and tumor invasiveness. |
| Molecular mechanism: |
circ-ATF7IP acts as a miR-488-3p sponge in PTC cells, relieving miR-488-3p-mediated post-transcriptional repression of IL13RA1 in macrophages and promoting IL13RA1-dependent M2 macrophage polarization and tumor microenvironment remodeling. |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); metastasis (promotes); macrophage polarization (promotes); immune regulation (promotes); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; FISH / smFISH; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Luciferase Reporter Assay; Flow Cytometry（Non-apoptosis/cycle）; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
circ-ATF7IP is a biomarker and predictive factor for PTC-related lymph node metastasis; AUC for predicting LNM was 0.704. |
| Description: |
circ-ATF7IP (hsa_circ_0025513) is up-regulated in LNM-positive PTC and may serve as a diagnostic/predictive biomarker for lymph node metastasis. Functionally, it promotes PTC proliferation, invasion, tumor growth, and macrophage migration by sponging miR-488-3p and modulating the miR-488-3p/IL13RA1 axis, thereby supporting M2 macrophage polarization and tumor microenvironment remodeling. |
| Confidence score: |
0.7736 |