| Expression pattern: |
DN |
| Associated gene: |
PEG3 |
| Associated microRNA: |
miR-582-3p |
| Biological function: |
Circ_0042986 acts as a tumor suppressor in cervical cancer, restraining CC cell growth, migration, invasion, angiogenesis, survival and in vivo tumorigenesis while promoting apoptosis. |
| Molecular mechanism: |
Circ_0042986 functions through a ceRNA mechanism by directly decoying miR-582-3p, thereby increasing PEG3 expression and blocking malignant progression of cervical cancer. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); angiogenesis (inhibits); apoptosis (promotes); ceRNA regulation (other); other pathway/process (inhibits) |
| Detected method: |
Q
S
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Transfection; EdU Staining; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Tube Formation Assay; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; RNA Pull-Down; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
Circ_0042986 may serve as a biomarker and therapeutic option for cervical cancer. |
| Description: |
Circ_0042986 is downregulated in cervical cancer tissues and cells. Restoring circ_0042986 suppresses malignant phenotypes and tumor growth by sponging miR-582-3p and increasing PEG3 expression, supporting its role as a tumor-suppressive circRNA and potential therapeutic option in cervical cancer. |
| Confidence score: |
0.8006 |