circRNA basic information
circBase ID: -
Name: hsa_circ_DHX34
Synonym: circDHX34
Host Gene: DHX34
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

MDA-MB-231
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: BCL2, BCL2L1, CASP8, CASP9
Associated microRNA: -
Biological function: Sodium arsenite-mediated upregulation of circDHX34 promotes apoptosis and represses proliferation in hormone-independent breast cancer MDA-MB-231 cells; knockdown of circDHX34 promotes cell proliferation and inhibits apoptosis.
Molecular mechanism: circDHX34 regulates apoptotic genes: knockdown upregulates antiapoptotic genes BCL2 and BCL2L1 and downregulates proapoptotic genes CASP8 and CASP9.
Biological pathway or process:

apoptosis (promotes); proliferation (inhibits)
Detected method:
Q
Validation methods:

RT-qPCR; Transfection; CCK8
Clinical significance:

-
Description:

In sodium arsenite-treated hormone-independent breast cancer MDA-MB-231 cells, circDHX34 is up-regulated in a dose-dependent manner. Functional knockdown experiments indicate that circDHX34 suppresses proliferation and promotes apoptosis, likely through regulation of apoptotic genes including BCL2, BCL2L1, CASP8 and CASP9.
Confidence score:

0.3513
Other information
Title:

Sodium arsenite-mediated upregulation of circDHX34 promotes apoptosis in hormone-independent breast cancer cells by regulating apoptotic genes.

Journal: Environmental science and pollution research international
Published: 2022
PubMed ID: 34378131
Study type:

biological research
Data availability: The datasets generated and analyzed during the current study are not publicly available because of the follow-up studies is conducting but are available from the corresponding author on reasonable request.
Code availability: -