circRNA basic information
circBase ID: hsa_circ_0000437
Name: -
Synonym: circ_0000437
Host Gene: -
Genomic location(hg19): chr12:109046047-109048186:-
Genomic location(hg38): chr12:108652271-108654410:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma / HCC
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissue; adjacent tissue; serum; plasma
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Serves as a diagnostic and prognostic biomarker for HCC (associated with clinicopathological features and overall survival).
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; ROC Analysis; Survival Analysis
Clinical significance:

Upregulated circ_0000437 in tissue and serum is associated with TNM classification, differentiation degree, tumor size and BCLC stage; high serum expression correlates with poor OS; serum AUC for HCC diagnosis is 0.9281.
Description:

In HCC, hsa_circ_0000437 (circ_0000437) is significantly up-regulated in tumor tissue and patient serum. Higher serum levels are associated with poorer overall survival and show high diagnostic performance (AUC 0.9281), supporting its use as a diagnostic/prognostic biomarker.
Confidence score:

0.5202
Other information
Title:

Circular RNA hsa_circ_0000437 may be used as a new indicator for the diagnosis and prognosis of hepatocellular carcinoma.

Journal: Bioengineered
Published: 2022
PubMed ID: 35730467
Study type:

combined biological and clinical study
Data availability: GSE166678; available from the corresponding author on reasonable request
Code availability: -