| Expression pattern: |
DN |
| Associated gene: |
ERG, Ago2 |
| Associated microRNA: |
miR-181a-5p |
| Biological function: |
Circ_0020093 overexpression promoted cell proliferation and alleviated IL-1beta-induced inflammatory response, apoptosis and ECM degradation in human chondrocytes. |
| Molecular mechanism: |
Circ_0020093 acts as a molecular sponge for miR-181a-5p, thereby promoting ERG expression and alleviating IL-1beta-induced chondrocyte injury. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); inflammation (inhibits); ceRNA regulation (other); other pathway/process (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RNA Pull-Down; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; ELISA; Western Blot; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Circ_0020093 had diagnostic value for OA, with ROC AUC of 0.73 in serum samples. |
| Description: |
Circ_0020093 is down-regulated in OA serum samples and IL-1beta-treated human chondrocytes. Its overexpression protects chondrocytes by promoting proliferation and suppressing inflammation, apoptosis and ECM degradation. Mechanistically, circ_0020093 sponges miR-181a-5p to relieve repression of ERG, and it also shows potential diagnostic value for OA. |
| Confidence score: |
0.8322 |