| Expression pattern: |
UP |
| Associated gene: |
H1, H2-N 3, DNA padlock probe, RCA products, MB@MOFs-TDN signal nanoprobes |
| Associated microRNA: |
- |
| Biological function: |
Serves as a serum biomarker for distinguishing HER2-positive breast cancer from TNBC and for breast cancer molecular typing and therapy monitoring. |
| Molecular mechanism: |
circ-HER2 is detected through competitive hybridization at its back-splice junction, which initiates rolling circle amplification and enhances self-assembly of MB@MOFs-TDN signal nanoprobes for electrochemical signal amplification. |
| Biological pathway or process: |
not specified |
| Detected method: |
Others
|
| Validation methods: |
Clinical Sample Validation |
| Clinical significance: |
Serum circ-HER2 detection can distinguish HER2-positive breast cancer from TNBC and may support breast cancer typing and HER2-targeted therapy monitoring. |
| Description: |
This study developed an RCA-enhanced MOF-based electrochemical biosensor to sensitively quantify serum circ-HER2. Serum circ-HER2 levels were higher in HER2-positive breast cancer samples than in TNBC samples, supporting its use for breast cancer molecular typing and potential HER2-targeted therapy monitoring. |
| Confidence score: |
0.208 |