| Expression pattern: |
DN |
| Associated gene: |
ADAMTSL5 |
| Associated microRNA: |
miR-644 |
| Biological function: |
Suppresses gastric cancer cell proliferation, invasion and migration; inhibits tumor growth in vivo |
| Molecular mechanism: |
Acts as a ceRNA sponge for miR-644 to upregulate ADAMTSL5 |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Transfection; MTT; Colony Formation Assay; Transwell Assay; RNA Pull-Down; Luciferase Reporter Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Clinical Sample Validation |
| Clinical significance: |
- |
| Description: |
circPFKP is down-regulated in gastric cancer and functions as a tumor suppressor by inhibiting proliferation, migration/invasion and xenograft growth. Mechanistically, it acts as a ceRNA sponge for miR-644, thereby increasing ADAMTSL5 expression (circPFKP/miR-644/ADAMTSL5 axis). |
| Confidence score: |
0.8508 |